Review Chng Ch Bt Ng Sn
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Asst Prof Ch’ng obtained his Bachelor of Science degree in Biology and Minor in Biochemistry from Davidson College, a liberal arts college in North Carolina, where he studied flagellar proteins in Chlamydomonas reinhardtii. He then completed his PhD research at Princeton University, New Jersey, in the laboratory of Dr Lynn Enquist, studying the molecular mechanism of transneuronal spread of alphaherpesvirus in the nervous system. After leaving Princeton University, Asst Prof Ch’ng pursued his postdoctoral research and was later promoted to a research fellow in the laboratory of Dr Kelsey Martin at University of California, Los Angeles, studying the molecular mechanisms of long term memory storage in the brain. In the lab, Asst Prof Ch’ng focused his research on a potent transcriptional coactivator known as CRTC1, and showed that this coactivator undergoes activity-dependent translocation from the synapse to the nucleus and that it plays a crucial role in transcription-dependent neuronal plasticity. The human brain is comprised ofbillions of neurons that form a highly interconnected circuit capable ofreceiving, processing and responding to a range of stimuli. As neuronalnetworks rewire with experience, these synaptic connections also undergo persistentexperience-dependent changes over time. This constant strengthening andweakening of synapses in response to neuronal activity is known as synapticplasticity and the long lasting forms of synaptic plasticity are theneurobiological foundations of learning and memory.
The laboratory employs amultidisciplinary approach using different neuronal preparations to studysignalling pathways and cellular event when neurons are activated duringlearning and memory. The techniques we use range from basic cell biology assays,protein biochemistry, live imaging to next generation sequencing technologiesto study how neurons receive, relay and respond to incoming signals required toinitiate a transcriptional response during experience-dependent rewiring ofneuronal connections. The lab is focused onunderstanding how soluble signals associated with long-lasting forms ofneuronal plasticity are relayed to the nucleus to alter gene expression. We areworking to identify and expand the catalogue of synaptic proteins that undergo nucleartranslocation as well as explore the kinetics and dynamics of thislong-distance transport. In the context of neuronal plasticity, we want toidentify what type of stimulus trigger synapse to nucleus signalling and howthese proteins subsequently regulate changes in gene expression critical forlong-term plasticity. Synaptic signals thatarrive at the nucleus can initiate a complex and robust response from thenucleus which includes modifications in the epigenome, transcriptome and compositionof the proteome.
Review Chng Ch Bt Ng Sn 3
We are interested in understanding how neuronal nuclei respondto activity-dependent changes in the context of memory formation and how thesepersistent alterations allow neurons to encode memories. Ultimately, we hope to get acomprehensive and dynamic snapshot of various nuclear processes critical forestablishing a memory engram. As a logical extension of this work, we want tounderstand how nuclear plasticity is impacted in diseased neurons and how thatrelates to memory loss. Neuronsrequire a tremendous of energy during learning and memory and the interactionbetween neurons and astrocytes is critical to maintain this function. We areinterested in understanding how the neuron-astrocyte relationship impactslearning and memory and how the transcriptional response in astrocytes andneurons helps to regulate the metabolic pathways required for proper neuronalfunction.
We also want to understand how metabolic imbalance or disease canimpact brain function particularly during memory formation.